{"id":4314,"date":"2024-06-14T18:18:57","date_gmt":"2024-06-14T15:18:57","guid":{"rendered":"https:\/\/uanimals.org\/media\/?p=4314"},"modified":"2024-12-19T14:11:54","modified_gmt":"2024-12-19T12:11:54","slug":"first-blood-donations-how-humanity-learned-to-transfuse-blood-and-what-animals-have-to-do-with-it","status":"publish","type":"post","link":"https:\/\/uanimals.org\/media\/en\/statti-en\/first-blood-donations-how-humanity-learned-to-transfuse-blood-and-what-animals-have-to-do-with-it\/","title":{"rendered":"First Blood Donations: How Humanity Learned to Transfuse Blood and What Animals Have to Do With It"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<span style=\"font-weight: 400;\">One blood donation <\/span><a href=\"https:\/\/www.nhlbi.nih.gov\/education\/blood\/donation\"><span style=\"font-weight: 400;\">can save<\/span><\/a><span style=\"font-weight: 400;\"> three people. Last year alone in Ukraine, donors <\/span><a href=\"https:\/\/www.donor.ua\/news\/2748\"><span style=\"font-weight: 400;\">gave blood<\/span><\/a><span style=\"font-weight: 400;\"> at least 14,000 times. So, over the years \u2014 even centuries \u2014 of blood transfusion history, millions of lives were saved. This was made possible thanks to animals, namely the first dog-to-dog blood transfusions. Let\u2019s dive into history and learn about the risky and often inhumane experiments that paved the way for modern blood donation \u2014 lifesaving and safe.<\/span><\/p>\n<h2><b>Liver or Heart: How the Circulatory System Works<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Imagine this: it\u2019s the early 17th century. Copernicus has already shown that the Earth revolves around the Sun. Yet people still do not fully understand the workings of their own bodies, particularly the circulatory system. Since Ancient Roman times, the <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21781247\/\"><span style=\"font-weight: 400;\">theory of Claudius Galen prevailed<\/span><\/a><span style=\"font-weight: 400;\">, claiming that the liver produces blood and distributes it throughout the body like a centrifuge.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But one man in the Kingdom of England set out to prove that these ideas were incorrect. This was physiologist and anatomist William Harvey. Observing the hearts of living animals, he realized that during systole (the contraction of the ventricles and atria), blood is pushed out. The scientist then demonstrated that valves in the veins allow blood to flow in only one direction \u2014 this is how the blood returns to the heart.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ultimately, William Harvey hypothesized that blood circulates in animal bodies. In the eighth chapter of his book \u201c<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2776239\/\"><span style=\"font-weight: 400;\">De Motu Cordis<\/span><\/a><span style=\"font-weight: 400;\">\u201d (\u201cOn the Motion of the Heart\u201d), he explained it like this: <em>\u201c\u2026through dissection of the living in order to experiment and through the opening of arteries, from the symmetry and magnitude of the ventricles of the heart and of the vessels entering and leaving\u2026 I had very often and seriously though about\u2026 how great the amount of transmitted blood would be [and] in how short a time that transmission would be effected\u2026 I began privately to think that it might rather have a certain movement, as it were, in a circle&#8230;.\u201d<\/em><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Thanks to William Harvey\u2019s research, he <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3721262\/\"><span style=\"font-weight: 400;\">discovered and described<\/span><\/a><span style=\"font-weight: 400;\"> in his research that:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The heart contracts 1,000 times in half an hour, initiating blood circulation;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">With each contraction, approximately 6 grams of blood pass through the heart, with its total capacity being 43 grams;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood moves in circles through the system of blood vessels in one direction (from the heart via arteries, and back via veins).<\/span><\/li>\n<\/ul>\n<h2><b>From the Theory of Circulation to the Practice of Transfusion<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Following William Harvey\u2019s discovery, the development of this branch of medical science accelerated, and by 1665, physician Richard Lower <\/span><a href=\"https:\/\/www.nhsbt.nhs.uk\/who-we-are\/a-history-of-donation-transfusion-and-transplantation\/\"><span style=\"font-weight: 400;\">conducted the first blood transfusion between dogs<\/span><\/a><span style=\"font-weight: 400;\">. For this, he drew blood from a medium-sized dog \u201c<\/span><a href=\"https:\/\/veteriankey.com\/evolution-of-veterinary-transfusion-medicine-and-blood-banking\/\"><span style=\"font-weight: 400;\">its strength was nearly gone<\/span><\/a><span style=\"font-weight: 400;\">\u201d and then transfused blood from two large mastiffs.<\/span><\/p>\n<blockquote><p><span style=\"font-weight: 400;\">The procedure was successful \u2014 an outcome tempting enough to try on humans. But there was a catch: at first, doctors experimented <\/span><a href=\"https:\/\/www.nhsbt.nhs.uk\/who-we-are\/a-history-of-donation-transfusion-and-transplantation\/\"><span style=\"font-weight: 400;\">not with human-to-human transfusions but with\u2026 animal blood<\/span><\/a><span style=\"font-weight: 400;\">. Such attempts were bound to result in losses: animal blood cannot mimic human blood due to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8157792\/\"><span style=\"font-weight: 400;\">differences in the properties of red blood cells<\/span><\/a><span style=\"font-weight: 400;\"> across species.<\/span><\/p><\/blockquote>\n<p><span style=\"font-weight: 400;\">However, some studies found that, among tested animals, sheep blood <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8157792\/\"><span style=\"font-weight: 400;\">most closely matches the viscosity of human blood<\/span><\/a><span style=\"font-weight: 400;\">. This explains the documented case of interspecies transfusion without fatal consequences: in 1667, French physician Jean-Baptiste Denys transfused blood from a lamb to a 15-year-old boy and a woman who had recently given birth. Both <\/span><a href=\"https:\/\/www.understandinganimalresearch.org.uk\/news\/from-animals-to-humans-how-blood-saves-lives\"><span style=\"font-weight: 400;\">survived<\/span><\/a><span style=\"font-weight: 400;\"> but suffered severe anemia. Not all experimental patients were so fortunate, and some cases <\/span><a href=\"https:\/\/www.britannica.com\/story\/the-strange-grisly-history-of-the-first-blood-transfusion\"><span style=\"font-weight: 400;\">resulted in death<\/span><\/a><span style=\"font-weight: 400;\">. Therefore, blood transfusions from animals to humans were soon <\/span><a href=\"https:\/\/www.aabb.org\/news-resources\/resources\/transfusion-medicine\/highlights-of-transfusion-medicine-history\"><span style=\"font-weight: 400;\">prohibited<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2><b>From Practice to Understanding the Principles of Donation<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">In 1818, scientist and physician James Blundell <\/span><a href=\"https:\/\/www.nhsbt.nhs.uk\/who-we-are\/a-history-of-donation-transfusion-and-transplantation\/\"><span style=\"font-weight: 400;\">performed<\/span><\/a><span style=\"font-weight: 400;\"> the first successful and documented human-to-human blood transfusion.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Blundell\u2019s patient was dying of postpartum hemorrhage, so to save the woman, the doctor <\/span><a href=\"https:\/\/collection.sciencemuseumgroup.org.uk\/objects\/co136087\/blundells-blood-transfusion-apparatus-london-england-1801-1900-blood-transfusion-apparatus\"><span style=\"font-weight: 400;\">used her husband<\/span><\/a><span style=\"font-weight: 400;\"> as the donor. Between 1825 and 1830, James Blundell conducted 10 blood transfusions, but only half were successful. Why was the blood sometimes unsuitable?<\/span><\/p>\n<blockquote><p><span style=\"font-weight: 400;\">It took science nearly nearly a century to figure out the concept of blood types and how critical they are for successful transfusion. We owe the most to Karl Landsteiner, who in the 1900s described all blood types and <\/span><a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/1930\/landsteiner\/biographical\/\"><span style=\"font-weight: 400;\">received<\/span><\/a><span style=\"font-weight: 400;\"> a Nobel Prize for his discovery.<\/span><\/p><\/blockquote>\n<p><span style=\"font-weight: 400;\">Notably, zoologists contributed to this progress as well. In 1875, one of them, Hermann Landois, <\/span><a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/1930\/landsteiner\/biographical\/\"><span style=\"font-weight: 400;\">discovered<\/span><\/a><span style=\"font-weight: 400;\"> that when animal blood is transfused into humans, foreign blood cells \u201cclump together\u201d and break down in the blood vessels, releasing hemoglobin. Between 1901 and 1903, Karl Landsteiner noted that a similar reaction occurs during human-to-human blood transfusions. This can cause shock, jaundice, and hemoglobinuria (abnormal breakdown of red blood cells), as seen during early attempts at transfusion.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At first, this reaction was overlooked. However, in 1909, Karl Landsteiner classified human blood into the now-familiar types A (II), B (III), AB (IV), and O (I). He demonstrated that when blood type A is transfused to a recipient with the same type, blood cells remain intact. But if blood from another type \u2014 B or AB \u2014 is transfused, the red blood cells are destroyed. Additionally, there are universal donors: people with the blood type O (I).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is just a brief outline of the journey toward a functional system of blood donation between humans. But let\u2019s admit, we owe many of these great discoveries to animals. So why shouldn\u2019t animals also benefit from science to live longer, healthier lives? Let\u2019s explore blood donation among animals.<\/span><\/p>\n<h2><b>Blood Donation in the Animal World<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Around the same time when human blood types were being studied, scientists were also researching dog blood types. However, a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8669569\/\"><span style=\"font-weight: 400;\">complete classification<\/span><\/a><span style=\"font-weight: 400;\"> wasn\u2019t achieved until the 1950s. For dogs, the DEA system (Dog Erythrocyte Antigen) is used, while for cats, the AB system is applied \u2014 somewhat <\/span><a href=\"https:\/\/laboklin.com\/en\/a-b-or-c-new-genetic-tests-for-feline-blood-groups\/\"><span style=\"font-weight: 400;\">resembling<\/span><\/a><span style=\"font-weight: 400;\"> the human blood type system.<\/span><\/p>\n<blockquote><p><span style=\"font-weight: 400;\">Animals that regularly participate in blood donation become true heroes. For instance, a dog named Woodie from Leicestershire, England, saved 88 dogs by regularly <\/span><a href=\"https:\/\/www.bbc.com\/news\/uk-england-leicestershire-58354825\"><span style=\"font-weight: 400;\">donating<\/span><\/a><span style=\"font-weight: 400;\"> his rare blood type.<\/span><\/p><\/blockquote>\n<p><span style=\"font-weight: 400;\">Entire blood banks are already being created to save animals. For example, the <\/span><a href=\"https:\/\/www.petbloodbankuk.org\/\"><span style=\"font-weight: 400;\">Pet Blood Bank<\/span><\/a><span style=\"font-weight: 400;\"> operates in the United Kingdom. In Ukraine, similar banks exist based at research institutions, veterinary clinics, or municipal enterprises like <\/span><a href=\"https:\/\/lkplev.com\/ua\/post\/rozpocav-robotu-persij-u-zahidnij-ukraini-bank-krovi-dla-tvarin-unikalnij-proekt-lkp-lev-ta-partneriv\"><span style=\"font-weight: 400;\">Lev<\/span><\/a><span style=\"font-weight: 400;\"> in Lviv.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, due to a shortage of animal donors, scientists are also searching for alternatives to blood products. Currently, synthetic colloids and oxyhemoglobin are being considered, but they are not yet effective. For example, synthetic colloids cannot carry oxygen, and oxyhemoglobin has limitations such as high cost and limited availability. Additionally, this type of hemoglobin performs its function for only 3 days.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Therefore, while researchers continue their work, finding donors must be simplified. For this purpose, UAnimals created the <\/span><a href=\"https:\/\/blood.uanimals.org\/\"><span style=\"font-weight: 400;\">Animal Donor Platform<\/span><\/a><span style=\"font-weight: 400;\">. Those whose cats and dogs can donate blood can register there, as well as those looking for donors for their pets. From there, the process works like a dating app, except the \u201cdate\u201d happens in a clinic and is often life-saving for the animal.<\/span><\/p>\n<blockquote><p><span style=\"font-weight: 400;\">The journey to inventing and perfecting blood donation was arduous, filled with mistakes and sacrifices. Let the knowledge gained save as many lives as possible \u2014 both human and animal.<\/span><\/p><\/blockquote>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]One blood donation can save three people. Last year alone in Ukraine, donors gave blood at least 14,000 times. So, over the years \u2014 even centuries \u2014 of blood transfusion history, millions of lives were saved. This was made possible thanks to animals, namely the first dog-to-dog blood transfusions. Let\u2019s dive into history and learn [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2536,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[29],"tags":[96,38,66],"topic":[76,30],"class_list":["post-4314","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-statti-en","tag-dogs","tag-nauka-en","tag-sobaky-en","topic-nadvazhlyvi-en","topic-dosvidcheni-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>First Blood Donations<\/title>\n<meta name=\"description\" content=\"We look back to the times when the foundations of blood donation were first being discovered. 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